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How Do Ideal Friend Preferences and Interaction Context Affect Friendship Formation? Evidence for a Domain- General Relationship Initiation Process
This research examined how people’s ideal friend preferences influence the friendship formation process. In an extension of prior research on romantic relationship initiation, we tested whether the match between participants’ ideals and a partner’s traits affected participants’ interest in forming a new friendship in three contexts: evaluating a potential friend’s profile, meeting in-person, and chatting online. Results revealed that participants were more interested in becoming friends with a partner whose traits matched (vs. mismatched) their ideal friend preferences when evaluating his or her profile. After a live interaction, however, the effect of the ideal-perceived trait match manipulation on participants’ friendship interest was substantially reduced in both in-person and online chatting contexts. People’s ideal friend preferences may influence their friendship interest more strongly in descriptive (i.e., indirect) than interactive (i.e., direct) contexts, a finding that mirrors prior results from the romantic domain and documents a role for domain-general relationship initiation processes
Simulated Quantum Computation of Global Minima
Finding the optimal solution to a complex optimization problem is of great
importance in practically all fields of science, technology, technical design
and econometrics. We demonstrate that a modified Grover's quantum algorithm can
be applied to real problems of finding a global minimum using modest numbers of
quantum bits. Calculations of the global minimum of simple test functions and
Lennard-Jones clusters have been carried out on a quantum computer simulator
using a modified Grover's algorithm. The number of function evaluations
reduced from O(N) in classical simulation to in quantum
simulation. We also show how the Grover's quantum algorithm can be combined
with the classical Pivot method for global optimization to treat larger
systems.Comment: 6 figures. Molecular Physics, in pres
Consensus statement on ischaemic stroke care in Hong Kong
Objective. To issue guidelines for the care of acute stroke in Hong Kong, with the target audience of all health care professionals who are involved in acute stroke care. Participants. The Hong Kong Neurological Society and the Hong Kong Stroke Society. Evidence. The panel applied the 'rule of evidence' used by the United States Agency for Health Care Policy and Research. When there is insufficient evidence, the recommendation was based on customary practice and was circulated among the members and fellows of the two societies before coming to a consensus. Consensus process. Group meetings were held in 2002 to review the literature about acute care for patients with ischaemic stroke and to issue a consensus statement with reference to the local health care system. Participants of the meetings were appointed by the councils of The Hong Kong Neurological Society and the Hong Kong Stroke Society. The draft statement was circulated among the members and fellows of the two societies for comments before it was finalised. Conclusions. Ischaemic stroke is a heavy health care burden to Hong Kong. The current consensus statement provides a framework to establish a multidisciplinary approach towards its acute management.published_or_final_versio
Transient ischaemic attack patients are often underevaluated: Authors' reply
published_or_final_versio
The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer-Containing Antibody-Drug Conjugates
Antibody–drug conjugates (ADC) containing pyrrolobenzodiazepine (PBD) dimers are being evaluated clinically in both hematologic and solid tumors. These include ADCT-301 (camidanlumab tesirine) and ADCT-402 (loncastuximab tesirine) in pivotal phase II trials that contain the payload tesirine, which releases the PBD dimer warhead SG3199. An important consideration in future clinical development is acquired resistance. The aim was to generate and characterize PBD acquired resistant cell lines in both hematologic and solid tumor settings. Human Karpas-299 (ALCL) and NCI-N87 (gastric cancer) cells were incubated with increasing IC50 doses of ADC (targeting CD25 and HER2, respectively) or SG3199 in a pulsed manner until stable acquired resistance was established. The level of resistance achieved was approximately 3,000-fold for ADCT-301 and 3-fold for SG3199 in Karpas-299, and 8-fold for ADCT-502 and 4-fold for SG3199 in NCI-N87. Cross-resistance between ADC and SG3199, and with an alternative PBD-containing ADC or PBD dimer was observed. The acquired resistant lines produced fewer DNA interstrand cross-links, indicating an upstream mechanism of resistance. Loss of antibody binding or internalization was not observed. A human drug transporter PCR Array revealed several genes upregulated in all the resistant cell lines, including ABCG2 and ABCC2, but not ABCB1(MDR1). These findings were confirmed by RT-PCR and Western blot, and inhibitors and siRNA knockdown of ABCG2 and ABCC2 recovered drug sensitivity. These data show that acquired resistance to PBD-ADCs and SG3199 can involve specific ATP-binding cassette drug transporters. This has clinical implications as potential biomarkers of resistance and for the rational design of drug combinations
High-resolution regional modeling of urban moisture island: mechanisms and implications on thermal comfort
The urban moisture island (UMI) can aggravate the thermal stress due to the urban heat island (UHI) in subtropical and tropical cities. In this study, we investigated the spatiotemporal variation patterns of UMI in Hong Kong, a subtropical coastal city, using the fine-resolution mesoscale Weather Research and Forecasting (WRF) model by integrating local climate zone (LCZ) maps based on the World Urban Database and Access Portal Tools (WUDAPT). Our results show that at regional scale, the UMI phenomenon tends to occur in coastal areas, possibly owing to rich moisture sources from sea breeze and inhibited moisture penetration due to barrier effects of mountains. Specifically, an all-day UMI effect was found in coastal low-density low-rise areas (LCZ5&8&10), while a nocturnal UMI effect and a daytime urban dry island (UDI) effect were found in coastal high-density high-rise areas (LCZ1&2). The UDI effect at daytime can be attributed to strong vertical moisture convection associated with intensive surface sensible heat fluxes in a strongly mixed urban boundary layer (UBL). The UMI effect at night can be attributed to blocked ventilation aisle, inhibited dewfall due to UHI, and weakened upward motion in a stable UBL. On the other hand, UMI can increase regional heat risks with additional 37.5% neighbourhoods in Extreme caution level and additional 6.1% neighbourhoods in Danger level. In addition, the impact of UMI on human thermal stress was found to be dominant at daytime in coastal low-density low-rise areas (LCZ5&8&10) and at nighttime in coastal high-density high-rise areas (LCZ1&2)
Algebraic Approach to Interacting Quantum Systems
We present an algebraic framework for interacting extended quantum systems to
study complex phenomena characterized by the coexistence and competition of
different states of matter. We start by showing how to connect different
(spin-particle-gauge) {\it languages} by means of exact mappings (isomorphisms)
that we name {\it dictionaries} and prove a fundamental theorem establishing
when two arbitrary languages can be connected. These mappings serve to unravel
symmetries which are hidden in one representation but become manifest in
another. In addition, we establish a formal link between seemingly unrelated
physical phenomena by changing the language of our model description. This link
leads to the idea of {\it universality} or equivalence. Moreover, we introduce
the novel concept of {\it emergent symmetry} as another symmetry guiding
principle. By introducing the notion of {\it hierarchical languages}, we
determine the quantum phase diagram of lattice models (previously unsolved) and
unveil hidden order parameters to explore new states of matter. Hierarchical
languages also constitute an essential tool to provide a unified description of
phases which compete and coexist. Overall, our framework provides a simple and
systematic methodology to predict and discover new kinds of orders. Another
aspect exploited by the present formalism is the relation between condensed
matter and lattice gauge theories through quantum link models. We conclude
discussing applications of these dictionaries to the area of quantum
information and computation with emphasis in building new models of computation
and quantum programming languages.Comment: 44 pages, 14 psfigures. Advances in Physics 53, 1 (2004
Quantum spin liquid states in the two dimensional kagome antiferromagnets, ZnxCu4-x(OD)6Cl2
A three-dimensional system of interacting spins typically develops static
long-range order when it is cooled. If the spins are quantum (S = 1/2),
however, novel quantum paramagnetic states may appear. The most highly sought
state among them is the resonating valence bond (RVB) state in which every pair
of neighboring quantum spins form entangled spin singlets (valence bonds) and
the singlets are quantum mechanically resonating amongst all the possible
highly degenerate pairing states. Here we provide experimental evidence for
such quantum paramagnetic states existing in frustrated antiferromagnets,
ZnxCu4-x(OD)6Cl2, where the S = 1/2 magnetic Cu2+ moments form layers of a
two-dimensional kagome lattice. We find that in Cu4(OD)6Cl2, where distorted
kagome planes are weakly coupled to each other, a dispersionless excitation
mode appears in the magnetic excitation spectrum below ~ 20 K, whose
characteristics resemble those of quantum spin singlets in a solid state, known
as a valence bond solid (VBS), that breaks translational symmetry. Doping
nonmagnetic Zn2+ ions reduces the distortion of the kagome lattice, and weakens
the interplane coupling but also dilutes the magnetic occupancy of the kagome
lattice. The VBS state is suppressed and for ZnCu3(OD)6Cl2 where the kagome
planes are undistorted and 90% occupied by the Cu2+ ions, the low energy spin
fluctuations in the spin liquid phase become featureless
Single shot cathode transverse momentum imaging in high brightness photoinjectors
In state of the art photoinjector electron sources, thermal emittance from photoemission dominates the final injector emittance. Therefore, low thermal emittance cathode developments and diagnostics are very important. Conventional thermal emittance measurements for the high gradient gun are time-consuming and thus thermal emittance is not measured as frequently as quantum efficiency during the lifetime of photocathodes, although both are important properties for the photoinjector optimizations. In this paper, a single shot measurement of photoemission transverse momentum, i.e., thermal emittance per rms laser spot size, is proposed for photocathode rf guns. By tuning the gun solenoid focusing, the electrons' transverse momenta at the cathode are imaged to a downstream screen, which enables a single shot measurement of both the rms value and the detailed spectra of the photoelectrons' transverse momenta. Both simulations and proof of principle experiments are reported
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